SREBF1

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Sterol regulatory element-binding protein 1 (SREBP-1) also known as sterol regulatory element-binding transcription factor 1 (SREBF1) is a protein that in humans is encoded by the SREBF1 gene.[1][2]

 

Contents

Function

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the LDL receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

SREBF1 has been shown to interact with TWIST2,[4] CREB-binding protein,[5] DAX1[6] and LMNA.[7]

See also

  • Sterol regulatory element-binding protein

References

  1. ^ Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS (Nov 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell 75 (1): 187–97. PMID 8402897. 
  2. ^ Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH (Jun 1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics 25 (3): 667–73. doi:10.1016/0888-7543(95)80009-B. PMID 7759101. 
  3. ^ "Entrez Gene: SREBF1 sterol regulatory element binding transcription factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6720. 
  4. ^ Lee, Yun Sok; Lee Hyoung Ho, Park Jiyoung, Yoo Eung Jae, Glackin Carlotta A, Choi Young Il, Jeon Sung Ho, Seong Rho Hyun, Park Sang Dai, Kim Jae Bum (Dec. 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. (England) 31 (24): 7165–74. doi:10.1093/nar/gkg934. PMC 291873. PMID 14654692. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291873. 
  5. ^ Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (Nov. 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes Dev. (UNITED STATES) 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. ISSN 0890-9369. PMID 8918891. 
  6. ^ Lopez, D; Shea-Eaton W, Sanchez M D, McLean M P (Dec. 2001). "DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1". Endocrinology (United States) 142 (12): 5097–106. doi:10.1210/en.142.12.5097. ISSN 0013-7227. PMID 11713202. 
  7. ^ Lloyd, David J; Trembath Richard C, Shackleton Sue (Apr. 2002). "A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies". Hum. Mol. Genet. (England) 11 (7): 769–77. doi:10.1093/hmg/11.7.769. ISSN 0964-6906. PMID 11929849. 

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